Ultima-Selank 5mg

MANUFACTURER Ultima Pharmaceuticals - US
WAREHOUSE USA Warehouse 5
SUBSTANCE Selank ,

Products are being shipped without brand labels for security reasons. The recent surge in biotechnology has allowed for the exploration of new biologically-active substances, including "cognitive enhancers" or "nootropics."

One notable compound is Selank, formerly referred to as "TP-7," which is categorized as a synthetic peptide — a small, artificially-created protein.

Selank is promoted as an anti-anxiety agent and is also claimed to enhance learning and boost energy, supposedly without side effects or addiction risks.

Selank is relatively small, significantly less than most naturally-occurring proteins. It was created at the Institute of Molecular Genetics (Russian Academy of Sciences) in collaboration with the V.V. Zakusov Research Institute of Pharmacology (Russian Academy of Medical Sciences), alongside its related drug, Semax.

Selank was developed by merging the sequence of a peptide known as tuftsin with another sequence that enhances its molecular stability. Tuftsin is naturally found in the body and is part of the natural antibody IgG.

Both tuftsin and Selank have been shown to lower anxiety and increase serotonin levels in rats, with Selank being somewhat more effective.

In Russia, Selank is approved for treating generalized anxiety disorder (GAD) and for its application as a nootropic. However, it has not been authorized by the FDA for any conditions. Regardless, Selank remains accessible in various countries, often marketed as a "nutritional supplement."

While the precise mechanisms by which Selank operates are not fully established, it is thought to partially function by stabilizing enkephalins in the bloodstream. Enkephalins are natural peptides believed to mitigate the stress response.

However, one study in mice did not confirm the stabilization of enkephalins after Selank administration, and the treated mice did not display significant anti-anxiety benefits.

Some cell studies suggest that Selank may interact with GABA receptors, which are typically linked to sedative effects. One study involving mice showed that Selank increased activity in inhibitory neurons dependent on GABA, leading to reduced overall brain activity, which aligns with sedative effects.

Additionally, some researchers have noted an increase in BDNF, a crucial neurotropic factor implicated in learning and memory. This mechanism might account for some of Selank's asserted cognitive benefits.

Selank has also been indicated to affect levels of the neurotransmitters norepinephrine, dopamine, and serotonin in mice. These neurotransmitters are widely recognized for their roles in motivation, focus, and pleasure.

One animal study found that Selank increased norepinephrine but decreased dopamine and serotonin levels. Conversely, in some other cases, Selank elevated both norepinephrine and dopamine levels while leaving serotonin unchanged. Thus, its specific effects and mechanisms still require clarification.

A preliminary clinical trial involving 62 participants revealed that those administered Selank reported fewer anxiety symptoms, particularly pronounced in individuals with pre-existing anxiety disorders. Similarly, another study with 60 anxious patients observed comparable benefits, which persisted for up to a week post the final dose. In a third trial, among 70 anxiety patients, Selank was noted to amplify the effects of phenazepam (an anti-anxiety medication banned in some U.S. states) while reportedly minimizing its adverse effects, such as drowsiness and memory impairment.

In animal research, Selank demonstrated an ability to reduce anxiety in mice, with more anxious mice displaying more notable behavioral changes post-treatment. Additionally, its anti-anxiety effects were observed in rats receiving daily treatment for four weeks.

While the evidence is limited, it implies Selank may help alleviate anxiety. However, further investigation is essential to validate its effectiveness and safety in humans. If you experience anxiety, consider discussing with your doctor whether Selank may be beneficial—keeping in mind that this supplement should not replace prescribed treatments.

In a 30-day study, Selank was reported to stabilize memory traces (potentially enhancing memory retention) in rats, although the specifics of these measurements remain unclear since memory traces are not identifiable as distinct locations in the brain. Another animal study indicated that Selank might help preserve memory in monkeys.

Human studies are currently lacking, and it is unknown what effects, if any, Selank may have on healthy human users. Its safety for such individuals, whether in the short or long term, remains uncertain, so caution is warranted until further research is conducted.

Research showed that when rats with toxin-induced brain damage were given Selank, their brain activity reportedly normalized.

Selank was found to reduce depressive symptoms (assessed via immobility in a forced swimming test) in mice, and interestingly, it showed greater effectiveness at lower doses compared to higher doses.

In one preliminary animal study, Selank injections reportedly led to increased antioxidant levels in the livers of stressed mice.

In a study with sedated cats, Selank was shown to lower blood pressure by about 30% for up to three minutes and to enhance blood flow to the brain by roughly 24% for up to ten minutes. While these initial findings suggest Selank may have temporary cardiovascular impacts, the brief duration of these effects raises questions about their strength or medical significance. Furthermore, these observations were limited to animals, leaving its effects on healthy humans uncertain.

Anxiety is a common symptom during alcohol withdrawal. In a study simulating high alcohol intake, rats were given a 10% ethanol solution for 24 weeks, and Selank reportedly alleviated anxiety symptoms after a 48-hour withdrawal period.

An animal study indicated that Selank treated rats on a high-fat diet experienced 35% less weight gain. Furthermore, total cholesterol levels dropped by over 58%, and blood glucose levels decreased by 23.5%.

In a study, breast cancer-affected mice receiving daily doses of Selank exhibited slower tumor growth and longer lifespans than untreated mice. However, this finding does not confirm any anticancer efficacy of Selank. Extensive research is necessary before considering it as a legitimate cancer treatment option, and it should never replace standard cancer therapies.

Post-treatment with Selank, increased levels of several inflammatory response genes were observed in the spleens of mice, suggesting some protective benefits against inflammation.

Selank has been shown to reduce the area of stomach ulcers in animal models, potentially by enhancing lymph flow to the stomach, which plays a vital role in the immune system. Nevertheless, extensive human studies are required to confirm these effects and their underlying mechanisms.

Selank was reported to elevate IL-6 levels in blood cells from patients with depression. IL-6 is an inflammatory protein that may aid in fighting infections. Moreover, in one cell-based study, Selank was shown to stimulate the release of interferons, molecules that combat viruses.

There are suggestions that Selank could protect cells from certain viral infections, but results from an animal study involving virus-infected mice have cast doubt on these antiviral benefits. Further research is needed to fully assess Selank's potential and limitations.