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Thyromazol

Thyromazol

  • Brand: Abdi Ibrahim
  • Product Code: Thyromazol
  • Availability: In Stock

  • $18.00



CLASSIFICATION Antithyroid Hormones
ACNE No
WATER RETENTION No
HBR No
HEPATOTOXICITY No
AROMATIZATION No
MANUFACTURER Abdi Ibrahim
WAREHOUSE International Warehouse 2
SUBSTANCE Methimazole ,

Methimazole is a medication used for managing hyperthyroidism, a condition characterized by excessive production of thyroid hormones by the thyroid gland. Additionally, it may be prescribed before thyroid surgery to reduce hormone levels and mitigate the effects of thyroid manipulation. In veterinary medicine, methimazole is also employed to treat hyperthyroidism in cats.

Mechanism of Action:

Methimazole works by inhibiting the enzyme thyroperoxidase, which plays a crucial role in the synthesis of thyroid hormones by converting iodide ions (I-) into iodine (I0). This process is essential for the incorporation of iodine into tyrosine residues on the hormone precursor thyroglobulin, which is necessary for the production of triiodothyronine (T3) and thyroxine (T4). However, methimazole does not interfere with the sodium-dependent iodide transporter found on the basolateral membranes of follicular cells; this inhibition would require the use of competitive inhibitors like perchlorate and thiocyanate. It acts at the site of CXCL10.

Adverse Effects:

While using methimazole, it is crucial to monitor for symptoms such as fever or sore throat, as these can indicate the onset of agranulocytosis, a rare but serious side effect associated with a reduction in white blood cell count, specifically neutropenia (a lack of neutrophils). A complete blood count (CBC) with differential is necessary to verify this condition, at which point the drug should be discontinued. The administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) may aid in recovery.

Other potential side effects include:

  • Skin rash
  • Itching
  • Unusual hair loss
  • Nausea
  • Vomiting
  • Altered sense of taste
  • Abnormal sensations (tingling, prickling, burning, tightness, and pulling)
  • Swelling
  • Pain in joints and muscles
  • Drowsiness
  • Dizziness
  • Decreased white blood cell count
  • Reduced platelet count
  • Aplasia cutis congenita (when exposed prenatally)

    • Individuals who may experience adverse effects include those who:

  • Take anticoagulants, such as warfarin (Coumadin), diabetes medications, digoxin (Lanoxin), theophylline (Theobid, Theo-Dur), and certain vitamins.
  • Have a history of blood disorders like leukopenia (low white blood cells), thrombocytopenia (low platelets), or aplastic anemia, or liver diseases such as hepatitis or jaundice.
  • Are pregnant, planning to become pregnant, or breastfeeding. In these cases, propylthiouracil is often used as an alternative anti-thyroid medication during pregnancy or breastfeeding. If a pregnancy occurs while on methimazole, transitioning to propylthiouracil may be recommended. Initial studies indicated potential risks to the fetus from methimazole; however, more recent research suggests that this may not necessarily be the case.
  • Are preparing for a surgical procedure, including dental surgeries.