CLASSIFICATION
Glycoprotein hormones, alpha polypeptide
DOSAGE
500-3000IU 1-3 times/week
ACNE
Possible
WATER RETENTION
No
HBR
No
HEPATOTOXICITY
No
AROMATIZATION
No
MANUFACTURER
MSD
WAREHOUSE
International Warehouse 2
SUBSTANCE
Human Chorionic Gonadotropin
,
Pregnyl 5000IU is an injectable medication produced by MSD, containing Human Chorionic Gonadotropin (hCG) as its active ingredient. This hormone is produced during pregnancy by the developing placenta and later by the syncytiotrophoblast, a component of the placenta. One of hCG's functions is to control appetite and promote the utilization of fat as energy. Additionally, hCG is used to induce ovulation and treat female infertility, as well as to enhance sperm production in men. Bodybuilders also utilize it during steroid cycles and post-cycle therapy to help maintain muscle gains and stimulate testosterone production.
Bodybuilders and athletes often use Pregnyl at the conclusion of an anabolic-androgenic steroid cycle to prevent muscle tissue breakdown. It also plays a critical role in restoring normal testicular function. Often, after extended steroid use, an athlete's testes may shrink, but Pregnyl can help return them to their normal size. When combined with a very low-calorie diet, athletes can effectively reduce excess fat while preserving muscle mass. Women may also take Pregnyl alongside a low-calorie diet to eliminate unwanted fat.
The typical dosage of Pregnyl during a cycle ranges from 500IU to 3000IU per week, administered 1 to 3 times weekly. More frequent injections help maintain stable blood levels, whereas a single large dose may elevate estrogen levels due to the aromatization of natural testosterone, potentially leading to gynecomastia. Some bodybuilders report using 6000IU over 6 days, but this can be risky and varies based on individual factors. For post-cycle therapy, smaller doses of about 250 – 500IU daily for 2 to 3 weeks are recommended to initiate the reversal of testicular atrophy. Bodybuilders should follow a cycle of hCG for 2 to 3 weeks, allowing at least one month off before starting another cycle, and it is advisable to begin hCG treatment towards the end of a steroid cycle, particularly in the last week.
Serious side effects associated with Pregnyl include severe pelvic pain, swelling of the limbs, abdominal pain and swelling, shortness of breath, weight gain, diarrhea, nausea, or vomiting. Common side effects can include headaches, restlessness or irritability, mild swelling or water retention, depression, breast tenderness or swelling, and pain, swelling, or irritation at the injection site. In boys, Pregnyl may lead to early signs of puberty, such as voice deepening, pubic hair growth, and increased acne or sweating.