Malegra-50

ACTIVE HALF-LIFE 5-12 hours
CLASSIFICATION PDE5 inhibitor
DOSAGE Men 25-200 mg/day
ACNE No
WATER RETENTION No
HBR Possible
HEPATOTOXICITY No
AROMATIZATION No
MANUFACTURER Sunrise Remedies
WAREHOUSE International Warehouse 1
SUBSTANCE Sildenafil ,

Malegra-50, a generic version of Viagra, is used to treat erectile dysfunction. It contains 50 mg of Sildenafil Citrate, which is an effective dose for addressing this condition. Although it requires a prescription, it is easily available online without a doctor's note. Its effects typically begin 30 to 45 minutes after consumption and can last approximately 3 to 4 hours. Malegra-50 is offered only as oral tablets. It is important to note that this medication can cause significant interactions and adverse effects with certain drugs, making it unsuitable for individuals with cardiovascular issues.

Manufactured by Sunrise Remedies Private Limited, the company has been operational since 1995 and is based in Ahmedabad, Gujarat, India. They offer a range of pharmaceutical and herbal products, including both ayurvedic and allopathic medications in various forms like capsules, tablets, liquids, and topical treatments. The company claims compliance with WHO GMP regulations and standards.

Sildenafil Citrate, the active component of Malegra, effectively inhibits phosphodiesterase Type 5 (PDE5) in the corpus cavernosum. This inhibition helps protect cyclic guanosine monophosphate (cGMP) from decomposition. As nitric oxide (NO) levels rise in the corpus cavernosum, it attaches to cGMP receptors, increasing cGMP levels. This ultimately relaxes the smooth muscles of the helicine arteries, allowing for increased blood flow to the penis, resulting in a firm erection.

Malegra-50 is a reliable option for treating erectile dysfunction in men. The sildenafil in the medication promotes increased blood flow to the penis, enhancing the firmness and strength of an erection. The effects can last approximately 4 to 6 hours, providing a lasting solution for erectile dysfunction. Unlike doses taken randomly, which may not have a lasting effect, adhering to a consistent dosing schedule is more effective.

For optimal results, Malegra-50 should be taken by a sexually aroused man about 25 to 30 minutes before anticipated sexual activity. It is recommended to take one tablet per day without exceeding this limit. A single dose can remain effective for around five to six hours, with effects in some cases lasting up to ten hours.

The side effects associated with Malegra-50 are generally similar to those seen with sildenafil citrate. These can include skin flushing, nausea, gastrointestinal discomfort, and light-headedness. Some patients may also experience swelling in the ankles and feet, and difficulties sleeping. In rare instances, it can cause serious symptoms, such as hearing loss. Overdose situations may lead to prolonged and painful erections, possibly accompanied by pain in the chest, jaw, or left arm.

Patients on protease inhibitors should use Malegra-50 cautiously because these medications for HIV can affect the metabolism of sildenafil, potentially intensifying its effects and side effects. Various other drugs, including the widely used antibiotic Erythromycin and the H2 antagonist Cimetidine for peptic ulcers, may interact with Malegra. It’s advisable to avoid using Malegra-50 alongside alpha-blockers, as this combination can dangerously lower blood pressure. While there have been no documented cases of such interactions, caution is warranted. Furthermore, Malegra is known to have adverse interactions with nitrates, which can lead to severe hypotension if used together.