ACTIVE HALF-LIFE
24 hours
CLASSIFICATION
Antibiotic / Macrolide Combination, Gastrointestinal Agent / Miscellaneous
DOSAGE
1530 mg/day
ACNE
No
WATER RETENTION
No
HBR
No
HEPATOTOXICITY
Low
AROMATIZATION
No
MANUFACTURER
Deva
WAREHOUSE
International Warehouse 2
SUBSTANCE
Amoxycillin
,
Clarithromycin
,
Lansoprazole
,
Uses of Trio
Trio is utilized for the treatment or prevention of gastrointestinal (GI) ulcers that arise due to infection.
Important Information to Discuss with Your Doctor Before Taking Trio
Inform your doctor if you are allergic to lansoprazole, amoxicillin, clarithromycin, any penicillin, or any other component of these medications.Disclose any allergies you have to other medications, foods, or substances, and mention the symptoms you've experienced, such as rashes, hives, itching, shortness of breath, wheezing, coughing, or swelling of the face, lips, tongue, or throat.Let your doctor know if you have previously experienced liver issues related to these medications.Mention if you have had a prolonged QT interval on an ECG or any other abnormal heart rhythms.If you have low magnesium levels, low potassium levels, or a slow heartbeat, make your doctor aware.State if you have kidney or liver disease and are taking colchicine.Discuss any other medications (prescription or over-the-counter), natural products, or vitamins you are taking that may interfere with lansoprazole, amoxicillin, and clarithromycin, particularly those used for high cholesterol, migraines, or mental health conditions.If you are taking any medications that may lead to abnormal heart rhythms (prolonged QT interval), consult your doctor or pharmacist.Notify your healthcare provider if you are breastfeeding or intend to breastfeed.Key Considerations While Taking Trio
Rarely, severe allergic reactions may occur. Consult your doctor if you have any concerns.Contact your doctor if you experience throat pain, chest pain, severe abdominal pain, difficulty swallowing, or symptoms of a bleeding ulcer, such as black, tarry, or bloody stools, vomiting blood, or vomit resembling coffee grounds.Refrain from consuming alcohol while on this medication.The use of this medicine may increase the risk of fractures in individuals with osteoporosis, particularly if used in high doses for over a year or in patients over 50. Discuss this risk with your doctor.Low magnesium levels have been reported in some patients taking this medication for extended periods, particularly after one year. Regular blood tests may be needed if you will be taking it long-term or if you are on other drugs like digoxin or diuretics; consult your doctor.Severe liver issues have been associated with this medication. Seek immediate medical attention if you notice symptoms suggesting liver problems, such as dark urine, fatigue, loss of appetite, stomach pain, pale stools, vomiting, or jaundice.An abnormal heart rhythm (long QT interval) may occur, especially when combined with certain other drugs. Seek help right away if you feel your heartbeat is irregular.There have been cases of lupus associated with this medication or exacerbation of pre-existing lupus. Inform your doctor if you have lupus and report any symptoms like a facial rash, sensitivity to sunlight, muscle or joint pain, or swelling in limbs.In rare instances, serious reactions may occur, displaying symptoms like fever, rash, swollen glands, and organ-related issues. Consult your doctor about any such reactions.If you have heart disease, inform your doctor, as some studies indicate a higher risk of mortality for those taking clarithromycin. Results, however, vary by study.Use caution if you are 65 years or older, as you may be more susceptible to adverse effects.Hormonal birth control methods may be less effective. Consider using additional contraceptive measures, such as condoms, while on this medication.This medication can pose risks to an unborn child if taken during pregnancy. Contact your doctor immediately if you are pregnant or conceive while taking Trio.Recommended Administration of Trio
Follow your doctor's instructions regarding the use of lansoprazole, amoxicillin, and clarithromycin. Pay attention to all the information provided and adhere to the guidelines closely.
To maximize benefits, ensure that you do not miss doses.Continue taking the medication as directed by your healthcare provider, even if you are feeling better.Take the medication before meals.If using sucralfate, ensure you take lansoprazole, amoxicillin, and clarithromycin at least 30 minutes prior to it.Inform all your healthcare providers, including doctors, nurses, pharmacists, and dentists, that you are taking lansoprazole, amoxicillin, and clarithromycin.If you have diabetes, avoid using Clinitest®; opt for alternate urine glucose tests like Clinistix® or Tes-Tape®.This medication might influence certain laboratory tests, so inform your healthcare providers and lab personnel.Monitor your blood work as recommended by your doctor and maintain open communication.This medication may affect the concentration of other drugs in your system; discuss with your doctor if you are taking any additional medications as closer monitoring of your blood may be necessary.Exercise caution if you have conditions that may lead to fragile bones (osteoporosis), such as alcohol consumption, smoking, steroid use, seizure medications, or a family history of osteoporosis. Discuss your risk factors with your doctor. 
