Selank 10mg

CLASSIFICATION Anxiolytic Peptide
ACNE No
WATER RETENTION No
HBR No
HEPATOTOXICITY No
AROMATIZATION No
MANUFACTURER Beligas
WAREHOUSE International Warehouse 3
SUBSTANCE Selank ,

The recent surge in biotechnology has paved the way for exploring new biologically-active substances, such as “cognitive enhancers” or “nootropics.”

One notable compound is Selank, formerly referred to as “TP-7.” It is classified as a synthetic peptide, which are small proteins designed artificially.

Selank has been promoted as an “anti-anxiety” agent and is said to enhance learning and boost energy levels without causing side effects or addiction risks. It is significantly smaller than most natural proteins and was developed by the Institute of Molecular Genetics (Russian Academy of Sciences) in collaboration with the V.V. Zakusov Research Institute of Pharmacology (Russian Academy of Medical Sciences), alongside a related drug known as Semax.

Selank was created by merging the sequence of a peptide called tuftsin with another sequence that enhances its molecular stability. Tuftsin is a naturally occurring peptide that forms part of the antibody IgG.

Research has shown that both tuftsin and Selank can decrease anxiety and elevate serotonin levels in rats, with Selank proving to be slightly more effective.

In Russia, Selank has received approval for treating generalized anxiety disorder (GAD) and as a nootropic, although it has not been authorized by the FDA for any use. It remains available in several countries, often marketed as a “nutritional supplement.”

While the precise mechanisms behind Selank remain uncertain, it is believed to stabilize enkephalins in the bloodstream. Enkephalins are natural peptides that help mitigate stress responses.

However, one study in mice did not demonstrate any enkephalin stabilization after administering Selank, nor did it indicate any significant anti-anxiety effects in the treated mice.

Some cellular studies suggest that Selank may bind to GABA receptors. Compounds that attach to GABA receptors typically exhibit sedative qualities. A mouse study showed that Selank increased activity in inhibitory neurons reliant on GABA, leading to decreased overall brain activity consistent with sedative effects.

Additionally, some researchers have observed a rise in BDNF, a vital neurotrophic factor linked to learning and memory, suggesting this may underpin some cognitive benefits attributed to Selank. It has also been reported to affect levels of the neurotransmitters norepinephrine, dopamine, and serotonin in mice—substances associated with motivation, focus, and pleasure.

In one mouse study, Selank was said to increase norepinephrine levels while decreasing dopamine and serotonin levels. Conversely, in another study, it was reported to elevate both norepinephrine and dopamine without changing serotonin levels. As such, the exact effects and mechanisms of Selank remain ambiguous.

A preliminary clinical trial involving 62 participants indicated that those given Selank experienced fewer anxiety symptoms, with more pronounced effects noted in those with existing anxiety disorders.

Similarly, in another trial with 60 patients dealing with anxiety and phobias, benefits were observed that persisted for up to a week following the last dose.

Additionally, in a study involving 70 anxiety patients, Selank reportedly enhanced the effects of phenazepam (an anti-anxiety medication banned in some U.S. states) while reducing adverse side effects like drowsiness and memory loss.

In animal studies, Selank has demonstrated effectiveness in reducing anxiety in mice, with greater effects noted in those initially more anxious. Remarkably, treatment over four weeks yielded anti-anxiety effects in rats as well.

Though the evidence is limited, it suggests that Selank may help alleviate anxiety; however, further research is necessary to determine its efficacy and safety for human use. If you are struggling with anxiety, consult your doctor regarding the potential benefits of Selank, but always follow their medical advice and prescriptions.

One trial showed that Selank might stabilize memory traces in rats over a 30-day period, though how these measurements were conducted is unclear since memory traces aren’t detectable as distinct locations in the brain.

Another study indicated that Selank could help preserve memory in monkeys.

Nevertheless, human studies are scarce, and it remains uncertain what effects, if any, Selank might have on healthy individuals. Safety for such users—short or long-term—also requires more investigation.

In one study, Selank was administered to rats with toxin-induced brain damage, reportedly restoring normal brain activity levels.

Selank has been observed to reduce symptoms of depression (as measured by reduced immobility in a forced swimming test) in mice, with increased effectiveness at lower doses.

A preliminary animal study indicated that Selank injections raised antioxidant levels in the livers of stressed mice.

In an animal study involving sedated cats, Selank reduced blood pressure by approximately 30% for up to three minutes and boosted blood flow to the brain by around 24% for up to ten minutes.

While these findings suggest that Selank may have short-term cardiovascular effects, the brief durations make these results challenging to interpret, indicating that the effects might not be strong or clinically significant. Additionally, these results lack confirmation in healthy human subjects.

Anxiety often accompanies alcohol withdrawal. In a study where rats were given a 10% ethanol solution for 24 weeks, Selank reportedly alleviated their anxiety levels following 48 hours of alcohol withdrawal.

In one animal study, rats on a high-fat diet experienced 35% less weight gain with Selank treatment. Moreover, their total cholesterol levels fell by over 58%, and blood glucose levels decreased by 23.5%.

In an animal study, breast cancer-infected mice treated with daily doses of Selank exhibited slower tumor growth and lived longer than untreated mice.

However, this preliminary result does not imply that Selank is viable for anticancer therapy, and extensive research is required to substantiate these findings for legitimate cancer treatment. Never replace standard cancer therapies with Selank or any other supplements.

Post-treatment with Selank, mice showed elevated levels of several inflammatory response genes in their spleens, suggesting potential protection against inflammation-related harm.

Selank has been reported to reduce stomach ulcer size in animal models, with some researchers theorizing that it enhances lymph flow to the stomach, which is crucial for immune function.

Yet, further human research is necessary to validate this effect and its underlying mechanisms.

Selank has been reported to increase IL-6 production in blood cells from depressed patients. IL-6 is involved in inflammation and immune responses.

Additionally, in a cell-based study, Selank was seen to promote the release of interferons, which are anti-viral agents.

While Selank is proposed to offer some protection against certain viral infections, one animal study with virus-infected mice did not reveal any antiviral benefits, raising questions about this potential application.